Edmundo Brito-de la Fuente from Fresenius Kabi Deutschland has published the following study: ‘Determination of dissolution profile and bioaccessibility of Ketosteril using an advanced gastrointestinal in vitro model’ in a recent edition of Dissolution Technologies.
For this study the TIM-1 model was set-up to specifically mimic conditions resembling patients with chronic kidney disease. Importantly, TIM-1 provided highly reproducible results that significantly outperformed classic dissolution methods regarding the predicted in vivo situation. In addition, this work shows the use of TIM technology in studying pathophysiological conditions, highlighting its use in studying human gastrointestinal behavior of compounds in health and disease.
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