The food and pharma industries are continuously developing novel products in relation to human health. A current topic is the worldwide problem of body weight management. Researchers are searching for products that influence satiation and satiety to control food intake and maintain a healthy body weight. The stomach plays a crucial role in initiating satiation and satiety due to its role of accommodating food and contributing to food intake regulation.
As part of oral drug development, reliable scientific data about the transit through the gastro-intestinal tract is needed, preferably in a time- and cost-efficient way. TNO Triskelion fulfils these requirements by offering gastro-intestinal testing with the TNO Triskelion gastroIntestinal Models (TIM). The TIM-1 and tiny-TIM systems simulate the dynamic conditions in the stomach and small intestine, whereas the TIM-2 system simulates the large intestine.
For TNO Triskelion, the New Year stands for change. Soon we will be launching our new branding campaign. We proudly present a sneak preview of our new logo and name. Our positioning is also expressed in a brand-new slogan: Research for better living. This reflects our ambition to support you with personal commitment, excellent research and professional advice in the development of products that contribute to the safety, health and vitality of your customers.
Ligand binding assays (LBA) are still the golden standard for the quantitative analysis of therapeutic proteins and protein biomarkers in biological matrices. Alternatively, bioanalytical methods for proteins have been developed using liquid chromatography and mass spectrometry (LC-MS) after enzymatic digestion (bottom-up approach). Quantitative LC-MS analysis of intact proteins (MW>5 kDa) for bioanalytical purposes is still in its infant stage.
Bisphenol A is a high production volume compound and used to produce polymers. Since several years, there has been controversy about the safety of Bisphenol A, related to its application in food contact materials such as baby bottles. Consequently, human exposure to Bisphenol A has been investigated in a number of biomonitoring studies.