TNO Triskelion has extensive experience in the quantitative analysis of (bio)pharmaceuticals and their metabolites in biological matrices. We offer an extensive range of bioassays and analytical techniques and experience in method development, method validation and sample analysis.
The bioanalytical services of TNO Triskelion include:
Development of sensitive and high-throughput bioanalytical methods – bioanalytical methods is one of the core competencies of our organisation.
Validation and study sample analysis in accordance with the OECD principles of Good Laboratory Practice (GLP)
We have expertise in dealing with the more challenging aspects of small molecules and biopharmaceuticals, such as plasma protein binding, adsorption and complex extraction procedures
The state-of-the-art techniques we use are:
UPLC-MS/MS (API 6500 and XEVO TQS)
Q-Exactive and LTQ Orbitrap
Surface Plasmon Resonance (SPR/Biacore®)
Immunoassays, such as ELISA, EIA and RIA, Meso Scale Discovery (MSD)
Real-time polymerase chain reaction (PCR)
Routine sample clean up: liquid-liquid extraction, protein precipitation, SPE