Inhalation toxicity testing requires state-of-the art generation and monitoring equipment, toxicological expertise and trained professionals to guarantee high-quality inhalation studies. TNO Triskelion BV can offer this, in custom-made study designs, to test your compound.
TNO Triskelion BV has built a long track record of using in vivo models in toxicology, with a recent extension to in vitro models. TNO Triskelion BV has the expertise to offer various research methodologies, including generation and monitoring techniques for gases, vapours and aerosols. Exposure durations vary from acute to chronic exposure, complying with OECD guidelines and conducted under GLP. Our lab is equipped to expose rodent and non-rodents by nose-only exposure or whole body exposure. Combinations of nose-only and whole body exposure can be incorporated in, for example, a 2-generation study to prevent intermitting the exposure of the pups.
Automated generation and monitoring of gas and vapour exposure
Inhalation studies with nanoparticles
Measurement of breathing parameters during exposure.
In vitro exposure to test atmospheres
Inhalation exposure in reproduction toxicity and immunology studies.
Efficiently incorporating genotoxicity studies in standard inhalation studies
Assessment of respiratory allergy
Our well-equipped inhalation laboratory and our close collaboration with other disciplines allow us to offer you an optimal study design. We will be happy to discuss any specific requirements you may have.