Triskelion’s food quality laboratories are working with ISO/IEC 17025 accreditation (L546). Tests are routinely performed in duplicate with quality control samples in each series and frequent proficiency tests using Standard Reference Materials and Round-Robin tests.
Our laboratory works in full compliance with the OECD principles of Good Laboratory Practice, as endorsed by the Dutch GLP Compliance Monitoring unit.
Triskelion is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC).
Triskelion animal experiment policy
(© 2018 Triskelion B.V., 1 February 2018)
Triskelion B.V. is an innovative contract research organization contributing to the development of high-quality and safe products that improve the health and well-being of people. In order to find the answers to certain scientific questions, the use of laboratory animals is unavoidable.
Triskelion only uses laboratory animals when a suitable alternative is not available and when the social significance provides a counterbalance to the possible discomfort of the animals.
In accordance with the Principles of Humane Experimental Technique (Russell & Burch (1959), advocating replacement, reduction and refinement (3R’s) of laboratory animal research), this kind of research is conducted using as few animals as possible, minimizing their discomfort while retaining the highest possible standard of scientific integrity.
Any scientific method replacing a method using living vertebrates.
Example 1: Triskelion has developed an in vitro model of the gastro-intestinal tract for studying digestive processes.
Example 2: prior to risk assessment of hazardous substances an extensive analysis of available data is performed (‘read across’). This may lead to the conclusion that the available data set is sufficient for the risk assessment. Consequently, additional animal studies would then be redundant.
Any scientific method enabling a reduction of the number of experimental animals by using optimal research strategy, study design and analysis of results and maximum control of variation.
Example: surplus animals are retained to enable personnel to practice. In that way biotechnical proficiency can be acquired, maintained and improved without the need to purchase extra animals.
Any method, addition or adjustment in an experiment which minimizes the discomfort of animals.
Example: in addition to optimal housing and care, the animals are provided with nesting material and other environmental enrichment. Furthermore, animals are socially housed (if this is not precluded by the experimental design).
The general management (license holder) is ultimately responsible for the well-being of the experimental animals. This is guaranteed by employing personnel who are qualified and competent to conduct or supervise animal experiments responsibly and in line with legislation (researchers, animal technicians, animal welfare officer and veterinarian). Proficiency is maintained by regular training.
Triskelion conducts animal experiments within the frameworks of:
- The principles governing the use of animals in experiments of the European Communities (Directive 2010/63/EC) and Dutch legislation (The revised Experiments on Animals Act, 2014)
- National and international legislation on consumer safety (including pharmaceuticals legislation), health and safety of personnel, environmental protection and other legislation regarding animals
And further in accordance with:
Triskelion works according to GLP (Good Laboratory Practice) conditions and is accredited by the AAALAC (Association for Assessment and Accreditation of Laboratory Animal Care). The latter is a voluntary accreditation that can only be acquired if all requirements are met to ensure that animal experiments are performed in a responsible way. This guarantees the well-being and safety of personnel and experimental animals.
Triskelion conducts only animal experiments licensed by the Central Authority for Scientific Procedures (advised by the Animal Ethical Committee) and after approval by the internal Animal Welfare Body, which checks whether applications comply with the license and legislation.
Annually, Triskelion presents the records of conducted animal experiments and used experimental animals to the Netherlands Food and Consumer Product Safety Authority. These data are also available on our website.
Triskelion takes responsibility for its own animal experiments, but also for outsourced experiments. Furthermore, responsibility throughout the chain is taken by audits of suppliers of experimental animals and products that are critical for the quality of the work.
Triskelion has established the Central Oversight Body for the Care of Animals and Humans. It is composed of a general director, an animal facility operational manager, the head of QHSE (Quality, Health, Safety and Environment), an animal welfare officer, a designated veterinarian, a medical doctor, a radiation expert and a biological safety expert. In this central consultative body all aspects related to animal experiments are discussed.
Any misconduct can be reported anonymously to a confidential advisor.
Whenever possible, we apply the principles of reduction, refinement and replacement when designing in vivo studies.
Actual numbers of used laboratory animals are summarized in annual reports (available in March 2018) and the facts and figures.
Areas of Expertise
Triskelion is organized around 5 expertise areas, namely:
• Analytical Services
• Kinetics & metabolism
• Registration Services & Risk Assessment